pip is configured with locations that require TLS/SSL, however the ssl module in Python is not available.
Collecting pyopenssl
Could not fetch URL https://pypi.python.org/simple/pyopenssl/: There was a problem confirming the ssl certificate: Can't connect to HTTPS URL because the SSL module is not available. - skipping
Could not find a version that satisfies the requirement pyopenssl (from versions: )
As of OS X 10.11, Apple no longer provides header files for the deprecated system version of OpenSSL which means that you will not be able to build the _ssl extension.